Tretinac (altro nome Accutane)

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

heart disease

high blood cholesterol or triglycerides

nflammatory bowel disease

liver disease

mental problems, such as depression, psychosis, attempted suicide, or a family history of mental problems

osteoporosis, osteomalacia, or other bone disorders

pancreatitis

an unusual or allergic reaction to isotretinoin, vitamin A or related drugs, parabens, other medicines, foods, dyes, or preservatives

pregnant or trying to get pregnant

breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Swallow these tablets whole. Do not chew, crush, or divide them. If this medicine upsets your stomach, take it with food or milk. Take your doses at regular intervals. Do not take your medicine more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 13 years of age, precautions do apply.
Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is less than four hours to your next dose, take only that dose and skip the missed dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

vitamins and other supplements containing vitamin A

This medicine may also interact with the following medications:

alcohol

benzoyl peroxide, salicylic acid, or other drying medicines used for acne

medicines for seizures

orlistat

other drugs that make you more sensitive to the sun such as sulfa drugs

progestin-only birth control hormones

st. john's wort

steroid medicines like prednisone or cortisone

tetracycline antibiotics like doxycycline and tetracycline

warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

You may experience a flare in your acne during the initial treatment period. You will need to see your doctor or health care professional monthly to get a new prescription and to check on your progress and for side effects.
Do not give blood while taking this medicine and for 30 days after completion of treatment to avoid exposing pregnant women to this medicine through the donated blood.
Some patients have become depressed or developed serious mental problems while taking this medicine or soon after stopping. Stop taking this medicine if you start feeling depressed or have thoughts of violence or suicide. Contact your doctor.
If you wear contact lenses, they may feel uncomfortable. If your eyes get dry, check with your eye doctor. This medicine may decrease your night vision or cause other changes in vision. If you experience any change in vision, stop taking this medicine and see an eye doctor.
This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
Cosmetic procedures to smooth your skin including waxing, dermabrasion, or laser therapy should be avoided during therapy and for at least 6 months after you stop because of the possibility of scarring. Check with your health care provider for advice about when you can have cosmetic procedures.
This medicine may affect your blood sugar levels. If you have diabetes check with your doctor or health care professional if you notice any change in your blood sugar tests.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

breathing problems

changes in menstrual cycle

changes in vision, like blurred or double vision or decreased night vision

chest pain

depression

dizziness

fainting

hearing loss or ringing in the ears

hives, skin rash

ncreased irritability, anger, aggression or thoughts of violence

ncreased urination and/or thirst or dark urine

rregular heartbeat

loss of interest in usual activities

muscle or joint pain

muscle weakness with or without pain

nausea and vomiting

severe diarrhea

severe headache

severe stomach pain

slurred speech or trouble swallowing

start to have thoughts about hurting yourself

swelling of face or mouth

unusual bruising or bleeding

yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

chapped lips

dry mouth, nose or skin

flushing

hair loss, increased fragility of hair

headache (mild)

Where should I keep my medicine?

Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.